SICKLE CELL DISEASE
PRE-TEST Two year old Zola and her parents recently moved to Ghana from the United States. Zola has been having many painful health problems and developmental delays .She has had troubles healing from cuts and wounds. She also suffers from severe swelling in her fingers and toes. Those symptoms are accompanied by fever,pallor,dehydration,fatigue and pneumonia-like symptoms. a)List 5 differential diagnoses. b)What is the most likely diagnosis? INTRODUCTION Sickle Cell Disease( SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin called Hemoglobin S (HbS). SCD is a chronic lifelong disease. It is hereditary and an autosomal recessive disease. Autosomal recessive means both your parents need to carry the trait before you could have SCD. Remember, Red blood cells contain HEMOGLOBIN and HEMOGLOBIN is made up of HEME/HAEM and GLOBIN .HAEM is an iron containing compound, while GLOBIN is a protein. There are 2 ALPHA (Alpha 1 and Al...